Further studies are warranted to assess the utility of MPV as a novel diagnostic screening tool for colon cancer. In addition, MPV was found to be independently associated with the presence of colon cancer. The findings show that patients with colon cancer have higher MPV levels compared with controls, and these are reduced after surgery. A positive correlation between MPV and tumor-nodule-metastases (TNM) stage was found. Surgical tumor resection resulted in a significant decrease in MPV levels (11.4 fL vs 10.7 fL p<0.001). Patients with colon cancer had higher MPV compared with controls. The odds ratios (ORs) and 95% confidence intervals (CIs) for colon cancer were calculated using multivariate logistic regression analyses across MPV quartiles. We measured MPV levels in 128 patients with colon cancer before and after surgery, and 128 controls matched for age, gender, body mass index (BMI) and smoking status. A medical disorder known as hyperthyroidism may also be evident when MPV is high with the platelet count at normal levels. They also had megaplatelets on their PBS Figure - 1. The aim of the study was to clarify the relevance of MPV in patients with colon cancer. High Mean Platelet Volume (high MPV) with normal platelet count can be a sign of chronic myeloid leukemia, a condition where there is an overproduction in a particular type of white blood cells. We observed that 53/100 patients had a high MPV value of more than 10.5 fl. Many people with CMML have enlarged spleens (an organ that lies just below the left rib cage).
The amount of blasts in CMML is below 20. Usually there are some abnormal cells, called blasts, in the bone marrow. Studies have proved that lower blood vitamin D levels were associated with high MPV. To obtain an accurate diagnosis, consult with your doctor or another health care professional.
Activated platelets play a key role in inflammation and atherothrombosis, with mean platelet volume (MPV) is an early marker of platelet activation. Often, the monocyte count is much higher, causing their total white blood cell count to become very high as well. High MPV is frequently associated with the causes listed below. Colon cancer is the second most common cancer in developed countries.